4th Annual BIOMEMS 2002 - Advances in Medical and Analytical ApplicationsApril 25 - 26, 2002 • Royal Sonesta Hotel • Cambridge, MA USA [ Overview | Agenda | Call for Posters | Register ] View Electronic Brochure (PDF)OverviewBiological MEMS research and development is one of the fastest growing areas in the MEMS industry. In it's 4th year, Biomems 2002 will examine the biomedical and bioanalytical innovations utilizing emerging fabrication techniques and applications that will provide more cost-effective, reliable and cutting-edge bioMEMS technologies.BioMEMS 2002 features an internationally recognized faculty of academic, government and industry leaders who will present the latest in new manufacturing developments, medical applications and up-and-coming analytical techniques. Some of the specific areas to be discussed will include:BioMedical Microsystems Biosensing and Biomarker Technologies Drug Delivery Microchip Fabrication and Analysis Microfluidics Don't miss this opportunity to find out the latest state of the art developments and promising techniques for micro fabrication and applications of bioMEMS in medicine and in the laboratory. You will hear of new discoveries, case studies and the strategies to keep you at the cutting edge of bioMEMS. Join the current and emerging leaders at this exciting conference.Related Links THE ASSOCIATION FOR THE ADVANCEMENT OF MEDICAL INSTRUMENTATION AgendaThursday, April 25, 20027:30 Registration, Poster/Exhibit Set Up, Coffee and Pastries 8:25 Chairperson's Opening Remarks 8:30 Keynote Address: Reliability of BioMEMS - Failure at a Small Scale The increasing development of BioMEMS applications naturally raises questions about their long term stability and reliability. The questions are valid, particularly because MEMS failure modes are not the same as macro-devices and also because the testing to detect those failure modes are similarly not standard. This presentation discusses reliability issues unique to MEMS and how BioMEMS developers should address them. Biomedical Microsystems9:10 BioMEMS and Microfluidics: Linking Nano The future will see BioMEMS integrate in vivo biomedical intervention with in vitro biotechnological analysis through microfluidic platforms. Total on-chip integration will enable the interrogation of multiple molecular signatures at the nanoscale. On the other hand, it will also provide platforms for automation of molecular assembly at the nanoscale. Nanotechnology will remain at the research and scientific stage if there is not a method to scale up the processes. We believe that microfluidics will be critical for this scale-up to succeed. In all of this, integrated microfluidic processors have overwhelming advantages over hybrid microfluidic solutions. This presentation will introduce several integration platforms and their unique applications. 9:40 Micro/Nanotechnology for Medical Applications Top-down fabrication micro/nanotechnologies yield great promises for breakthrough advances in the "smart" delivery of therapeutic agents -where by "smart" we refer to biological targeting options, timed-release profiles, and both. In this presentation, we demostrate the advantages of this novel technological approaches by describing our recent results in the oral delivery of peptides, the controlled release of biotechnological molecules from implantables, and a new class of injectable microparticles. 10:10 Smart and Disposable Plastic Lab-on-a-chip for Point-of-Care Clinical Diagnostics Recently, an innovative, fully integrated, plastic microfluidic chip has been developed by UC-BioMEMS team for the dual applications of a fully stand-alone biochip as well as a wrist watch-type point of care system. We will present an easy-to-handle and inexpensive clinical diagnostic biochip using fully integrated plastic lab-on-a-chips, which have the sampling/identifying capability of fast and reliable measurements of metabolic parameters or diagnostics of specific biomarkers from a human body with minimum invasion. In this presentation, an overview of our recent research achievements for the smart and disposable plastic biochips for blood analysis and point-of-care System will be presented, discussing the relevant issues to the design, fabrication, and characterization of biochemical detections systems and disposable plastic biochips. 10:40 Refreshment Break and Poster/Exhibit Viewing 11:10 Biomedical Microsystems for Minimally Invasive Medical Procedures This presentation will: (1) explore the challenges that must be overcome for the successful deployment of MEMS technology in minimally invasive medical procedures; and (2) present an overview of biomedical microsystems that are currently under development for applications within a clinical context including devices for cardiology, neurology, and orthopedics. 11:40 The Use of MEMS in Surgery Often overlooked in the BioMEMS space, surgical tools benefit greatly from incorporating MEMS technology. Miniature low-cost MEMS transducers not only improve the functionality of existing surgical tools; but have also spawned entirely new devices, giving surgeons an unprecedented level of control and the flexibility to perform entirely new procedures. This talk will review current and future uses of MEMS in a wide range of surgical applications. Examples of Verimetra's MEMS technology applied to minimally invasive surgery will be presented. 12:10 Polymer-Based Biomedical Microsystems Polymer-based microfabrication processes have been applied to a number of biomedical microsystems under development at Lawrence Livermore National Laboratory. PDMS processing techniques developed by the Whitesides group and others have been enhanced to enable the fabrication of thin, compliant devices with conducting lines for medical implants, and hybrid microfluidic systems. Applications include biological sample preparation, electrode arrays for retinal implants, and microfluidic systems with integrated electronics. 12:40 Lunch Sponsored by The Knowledge Foundation Biosensing and Biomarker Technologies2:00 Chairperson's Opening Remarks 2:05 Cells in Micropatterned Hydrogels: Applications in Biosensing Here we will discuss the development of arrays of mammalian cells of differing phenotype integrated with microfluidics and microsensors for use in drug screening for example and used to monitor cellular effects of multiple chemical and biological candidates. To fabricate these arrays, we immobilize either single or small groups of cells in 3-dimensional hydrogel microstructures fabricated on plastic or glass surfaces. The specific and non-specific response of these cells to target molecules is monitored using optical or electrochemical detectors and analyzed to quantify the effect of these agents on the different phenotypes present in the array. 2:35 Microreplicated Plastic Label-Free Biosensor Arrays for High Throughput Genomics, Proteomics, and Diagnostics Applications SRU Biosystems is developing a high sensitivity plastic Biomolecular Interaction Detection (BIND) biosensor based on detection of changes in optical density on the surface of a narrow bandwidth guided mode resonant filter. Using sub-micron microreplication of a silicon structure on continuous sheets of plastic film, the sensor can be produced inexpensively over large surface areas. The sensor structure is incorporated into standard microtiter plates, microarray slides, and microfluid flow channels. This talk will describe how the BIND technology can be used to address various problems in drug discovery, genomics, and proteomics. 3:05 Nanobarcodes for Multiplexed Biomarker Discovery Nanobarcodes (NBC's) represents an exciting new approach to biomarker discovery and other biotechnology applications. Derived from photolithographic templates and MEMS processing methods, NBC's are encoded sub-micrometer sized metal particles functionalized with biomolecules important to multiplexed genomic, proteomic, and other applications. This paper reviews the basic fabrication, biomolecular functionalization, and optical readout of multiplexed assays based on NBC's. 3:35 Refreshment Break and Poster/Exhibit Viewing Drug Delivery4:00 Nanopores for Drug Delivery Nanoporous membranes, with 7-49 nm pore sizes, can perform size-based exclusion and controlled diffusion of biomolecules. Membranes allow diffusion of small therapeutic molecules, while excluding passage of larger proteins. The diffusion processes follow zero order kinetics, and are linearly dependent on the pore size short term. The membrane semipermeability, biocompatibility, ease in sterilization, and thermal and chemical stability, may provide significant advantages in cell immunoisolation and controlled drug delivery applications. 4:30 Micromechanical Systems for Intravascular Drug and Gene Delivery Sharp, high aspect ratio microstructures fabricated using silicon micromachining have been successfully used to deliver DNA into cells as an alternative to bombardment and microinjection. This idea can be extended to intravascular stents with integrated microprobes capable of piercing compressed plaque and delivering anti-restenosis therapies, both drugs and genes, into coronary arteries. Experiments have demonstrated successful transection of the internal elastic lamina in atherosclerotic vessels, and prototype drug delivery devices have been realized in stainless steel. Such localized delivery is critical in situations where minimally invasive techniques (such as catheterization) present optimal results in accessing internal body tissues or where the toxicity of the treatment drug may lead to adverse side effects if administered systemically. 5:00 Implantable BioMEMS for Drug Delivery BioMEMS technology is enabling the creation of intelligent drug delivery systems. Typical microchip systems include an array of sealed micro-reservoirs, where each reservoir is filled with a chemical and can be released on demand. Our group was the first to demonstrate the storage and in vitro release of multiple chemicals from a microchip, and recently, we achieved in vivo chemical release from subcutaneous implanted microchip devices. This talk will cover recent progress in the development of implantable bioMEMS for drug delivery applications. 5:30 Microfluidics and Drug Delivery Control of fluid delivery in medicine, especially pharmaceuticals, has in the past required pumps, or bags on poles, or both to achieve the correct dosing over time. With recent progress in MEMS, especially in microfluidics, comes the likelihood of much smaller, more convenient, and user-friendly drug administration systems. This presentation will cover recent advances in drug delivery using MEMS devices, and one particularly attractive system in some detail. 6:00 End of Day One Friday, April 26, 20028:00 Coffee and Pastries, Poster/Exhibit Viewing Microchip Fabrication and Analysis8:55 Chairperson's Opening Remarks 9:00 Fabrication of Microfluidic Sample Preparation and Chemical Separation Biochips A key to Micronic's success is the capability for rapid, parallel microfluidic device prototyping. The development cycle, from concept, design, prototype fabrication and test results of Micronics devices, can be routinely measured in hours. Fabrication of various microfluidic formats such as 96 microtiter plate, credit card, and postage stamp sized devices as well as hybrid designs (plastic & silicon) will be discussed. The database permitting parallel project development that follows a device from concept through testing as well as the process for scale up and manufacturing of disposable microfluidic devices will be presented. 9:30 Plastic Microfluidic Arrays Manufactured Using Microfabrication Technology: Bioassay Applications Plastic microfluidic array platforms and synergistic multiplexed assay chemistries are under development for applications including assays of gene expression, proteomics, genotyping, DNA sequencing and fragment analysis, sample preparation, and high-throughput pharmaceutical discovery. Zero-defect "master" templates of these device arrays are made using microfabrication technologies, and the master is then used to electroform an injection molding tool that allows low-cost, high-volume manufacture of disposable plastic parts. 10:00 Fabrication and Application of Plastic Microstructures for Chemistry and the Life Sciences Using predominantly tools that were developed for microelectronics, microfluidic structures for chemical and biochemical analyses have almost exclusively been realized in semiconductor materials like silicon. Material properties of silicon, e.g. chemical instability at high pH, make plastics an interesting alternative for the fabrication of microfluidic structures. Fabrication techniques like embossing, micro-injection moulding, and laser ablation will be discussed. Several applications based on plastic microstructures will be presented. 10:30 Refreshment Break and Poster/Exhibit Viewing 11:00 The Living Chip Micro-Bioassay System The Living Chip is a microarray technology, with the potential to initiate and monitor 103-105 bioassays in parallel with ~100nl total volume per assay. The Living Chip consists of a precisely constructed, high density array of micro-channels, in a plate. Liquids, including cell suspensions, buffers and sera, are transferred into the hydrophilic channels by capillary forces. Results from antibody binding assays, enzyme library screening, yeast-based androgen receptor bioassays, and other bioapplications will be presented. 11:30 Manipulation Technologies of Micro-objects for BioMEMS Several manipulation technologies of micro-objects for BioMEMS will be introduced. At first, manipulation methods of micro-objects in liquid are classified and briefly reviewed. Mechanical micromanipulation, non-contact micromanipulation using laser trap or dielectrophoresis, and self-assembly of the micro-objects are introduced. We also explain the recent development of the minimum invasive micromanipulation of the microbe using laser trapped micro-tools. We will see the non-contact micromanipulation is suitable for BioMEMS application. Finally we introduce the application example of these methods to the selective separation of the microbe with the micro-chip fabrication technology. 12:00 Lunch on Your Own Microfluidics1:25 Chairperson's Opening Remarks 1:30 MicroFluidics and BioMEMS Research at Berkeley BioMEMS is a rapidly growing area enabled by new approaches for fluid control and is a research thrust of the new Bioengineering Department at UC Berkeley. Current work on the design and development of microfluidic components such as micro-pumps, micro-valves, and micro-mixers and their integration will be presented. In addition to MEMS design, research on fundamental fluid mechanics of complex biological fluids in micro-devices will also be discussed. 2:00 Micro Fluidic Systems for Electrophysiological Analysis of Single Cells Micro systems technologies enable the realization of complex bio-analysis systems capable of interfacing with single cells using integrated electrical, optical, mechanical and chemical functionality. Interfacing cells with micro systems is interesting for applications ranging from biochemical sensors and drug discovery to basic electrophysiological analysis. This presentation will contain a discussion of the design, fabrication, and characterization of micro fluidic systems capable of electrically and chemically interfacing with single cells in a highly parallel fashion. 2:30 Microarray User Interface Device: Active and Passive Fluid Control for Improved Sensitivity and Reproducibility in Microarray Processing A MicroArray User Interface (MAUI) will be described which employs active and Passive Fluid Control to provide precise reagent and sample delivery to all areas of the microarray. The objective of this approach is to provide greater precision and reproducibility in microarray analyses for drug discovery, diagnostic and genomic applications. Results illustrating these features in various research applications of gene expression microarrays will be presented. 3:00 Refreshment Break and Poster/Exhibit Viewing 3:30 Benefits of Polymer-Based Microfluidic Devices The acceptance of bioMEMS in biomedical applications strongly correlates with their costs, easy handling, reliability and reproducibility as well as the simplicity of the instrumentation, which is needed for incubation and detection. Microfluidic reaction platforms in microtiter plate or microscopic slide formats can be designed to integrate typical assay steps like flow propulsion, dosing, mixing or washing. Of similar importance is the capability to mass fabricate such Lab-on-a-Chip devices in a cost effective way, e.g. by injection molding. STEAG microParts has developed and mass fabricates such devices with integrated microfluidics in polymers. Recent developments in molding and assembly technologies allow the fabrication of polymer devices with superior flatness and extremely low fluorescent background. Providing well suited surface properties STEAG microParts has developed novel polymer based devices for integrated DNA arrays and assays. Results on the performance of these BioMEMS will be presented. *In collaboration with Dr. Ralf-Peter Peters, Microfluidics, STEAG microParts GmbH 4:00 Multidisciplinary Simulation Software for Design Analysis and Optimization of Microfluidics Devices and Biomolecular Assays High-fidelity multi-physics simulation tools that describe the underlying physico-chemical processes governing the function of biomicrofluidics devices, are an emerging technology which allow biochip designers to rapidly create, test and modify "virtual" device prototypes and biomolecular assays on a computer. Their widespread application has the potential to revolutionize the pace of development of new biomicrofluidics products and IP portfolios. Sample applications of these design tools for devices such as microdispensers, DNA/proteomic biochips, immunosensors and electrochemical glucose sensors will be demonstrated in Call for PostersCall for Posters Register
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