5th Annual COMBI 2003 - Combinatorial Approaches for New Materials Discovery

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Overview

In its 5^th year this internationally recognized meeting will review the latest achievements in highthroughput and combinatorial approaches for novel materials discovery and technology development. In addition to comprehensive plenary sessions addressing the latest issues and trends in such "traditional" combi fields as:

• High throughput catalytic science


• Combinatorial inorganic, organic, and bio-organic materials development


• Complex functional materials


• Highthroughput experiment and library design

• Nanostructured materials


• Advanced ceramics


• Coatings and thin films


• Microelectronic and microphotonic materials


• Creating commercial value by using combi


• Ink-jet methods in combinatorial materials discovery


• Molecularly imprinted polymers via parallel synthesis


• Combi methods to develop materials for MEMS and sensors

NEW THIS YEAR!

This full-day seminar will examine the gap between enormous amounts of data created by combinatorial and high-throughput materials science experimentation and conversion of such data into usable information. Topics covered by leading scientists from multidisciplinary government and academic research labs in addition to the wide range of perspectives from start-up companies to global corporations include:

• Materials informatics - leveraging from 'pharma'


• Tailoring materials chemistry through informatics


• Global positioning in chemical space


• Deterministic method of experimental design


• IP licensing in the combi industry


• Optimal materials library design

Pre-Conference Seminar Co-Organizer:

NIST Combinatorial Methods Center

Endorsing Publications:

Elsevier Science
High Throughput Experimentation.com
NanoTechWeb

Sponsoring Organizations/Exhibitors:

Bruker AXS
Hysitron, Inc.

Agenda

Wednesday, February 19, 2003

8:00 Registration, Poster/Exhibit Set-Up, Coffee and Pastries

8:45 Chairperson's Opening Remarks and Introduction
Eric J. Amis, PhD, Chief, Polymers Division, National Institute of Standards & Technology

9:00 A Rational Framework for the Design of Catalysts
W. Nicholas Delgass, PhD, Professor & Associate Head, School of Chemical Engineering, Purdue University
In this approach, a forward model, linking catalyst descriptors to performance, and an inverse model, an evolutionary search for descriptors matching a targeted performance, are used in concert to extract knowledge from high throughput data. HTE/model-revision cycles provide convergence of the forward model to the desired prediction accuracy. An inverse model search, aided by a robust forward model, represents true catalyst design. The status of the framework development and application will be discussed.

9:35 Tailoring Materials Chemistry Through Informatics:
Reducing the Combinations for Industrial Needs
Krishna Rajan, PhD, Professor, Dept Materials Science & Engineering and Faculty of Information Technology, Rensselaer Polytechnic Institute
Combinatorial methods in materials synthesis generally focus on selecting and finding new chemistries of materials that may provide a desired property response. In this talk we demonstrate how the use of informatics strategies coupled with computational materials science can significantly narrow down the number of combinations in chemical synthesis that need to be explored. Examples including the design of new semiconductor alloys, and how we can extend the concept of bandgap engineering to the development of "virtual" materials. We also show how we have used this strategy for the chemical design of ultrahard ceramics. The use of the combination of these approaches when integrated with the correct types of descriptors, allows informatics methodologies to be a powerful computational methodology for materials design. The potential advantages of this combined informatics / physical modeling approach to combinatorial materials design in industry is also discussed.

10:10 Refreshment Break - Poster/Exhibit Viewing

10:30 Global Positioning in Chemical Space: The ChemGPS Concept
Tudor I. Oprea, MD, PhD, Professor and Director, University of New Mexico School of Medicine
Chemography, the art of chemical space navigation, requires rules (dimensions), and a predefined set of chemical structures (objects). ChemGPS "satellites" are intentionally derived extrema, while a representative set of drugs ("core" structures) keeps the model centered on the drug space. ChemGPS dimensions in drug space relate to size, lipophilicity, hydrogen bond capacity (2D level), as well as passive permeability and intrinsic solubility (3D level). This concept can be extended to polymers, if appropriate rules and objects are defined.

11:05 Building Combi Small - Challenges with Limited Resources
Alamgir Karim, PhD, Group Leader, Multivariant Measurement Methods Group, Polymers Division, National Institute of Standards and Technology
Due to successes in pharmaceuticals research, combinatorial and high-throughput methods for searching composition space have received increasing attention and more recently, it has been applied for materials research. One of the challenges in materials science affecting the adoption of combinatorial methods by industry and academia is the perception of a high barrier to entry into these methods. Recently, we have developed novel technologies for depositing coatings libraries that employ continuous gradients in thickness, composition, and temperature that are relatively inexpensive, yet yield insights into physical problems in materials science. The NIST Combinatorial Methods Center (NCMC) has been stablished as a model for collaboration with industry, academia and other federal laboratories in order to share expertise, facilities, resources, and information to lower the barrier to entry into combinatorial materials science.

11:40 IP Licensing in the Combi Industry
Irving S. Rappaport, Vice President, Intellectual Property Licensing Business, Symyx Technologies, Inc.
This presentation will focus on the importance of intellectual property (IP) licensing to the orderly development and maturation of the combinatorial and high throughput catalysis and materials development industry. As this field grows, it is important that all the players recognize one another's contributions to the field. All companies involved in the combi arena need to know that their contributions to the field, made through their R & D efforts and protected in their IP portfolios, will be honored by those newly entering the field. The absence of such recognition leads to chaos and what could be very costly and unproductive legal battles between competitors. IP licensing is one of the mechanisms that will help promote an orderly development of the field. It is in the interests of all parties in the combi field to find business solutions to the IP issues confronting the industry. Symyx has started its IP Licensing Business unit so as to find business solutions to deal with IP issues and to avoid resorting to costly, unproductive litigation. Symyx intends to not only be a leader in the development of the industry but to lead the way for the industry to find win-win business solutions in dealing with the industry's IP issues.

12:15 Lunch

1:40 Chairperson's Remarks
Michael J. Fasolka, PhD, Materials Research Engineer, Polymers Division, NIST Combinatorial Methods Center, National Institute of Standards and Technology

1:45 A Deterministic Method of Experimental Design
Brian K. Southern, PhD, President, Accelics, Inc.
Classical approaches to designing newer chemical experiments, to cover a spectrum of possibilities, involve varying all possible variables related to a parent experiment. Such an approach yields an array of experiments, which when performed produce responses that vary over a wide range. Determining the optimum experiment or direction of future experiments, based on these responses, depends on the ability to manage extremely vast quantities of data, the ability to perform such an array of experiments, and the quality of the responses. A deterministic method of experimental design is presented that provides improved data in less time, to provide an experimental design method, wherein analysis of data generated in real-time provides for updated experimental design, resulting in on-the-fly experiment amendment or truncation. Wherein initial experimental boundaries are determined by theoretical parameters; revised experimentation boundaries are determined through an analysis of these initial experimental boundaries in view of reference and experimental data; and experimental choices are determined based upon responses generated by a modeling tool.

2:20 Challenges of Combinatorial Thin Film Synthesis of Transition Metal Oxides
Mikk Lippmaa, PhD, Associate Professor, Institute for Solid State Physics, Tokyo University, Japan
The main problem with combinatorial solid state synthesis of transition metal oxide thin films is not the volume of measurement data, but rather the need to guarantee data integrity. Accurate synthesis process control and monitoring must therefore be combined with a large number of library characterization techniques to make sure that combinatorial screening or mapping results for a particular material property do indeed apply to the desired or assumed crystal structures.

2:55 Development and Application of a Combinatorial Capability for Rapid Delivery of Heterogeneous Catalyst
David S. Bem, PhD, Technology Director, Torial Technologies LLC, and
Duncan Akporiaye, PhD, Senior Scientist, SINTEF, Norway
SINTEF and UOP LLC have been developing combinatorial tools for heterogeneous catalysis research for several years and have constructed an integrated End-to-End^TM capability for discovery and optimization of heterogeneous catalyst. We will discuss this capability and the informatics required to allow flexible, practical operation for discovery and optimization research. Additionally, we will report the application of our integrated End-to-End^TM capability for the identification and subsequent development of a next generation catalyst for paraffin isomerization. We will demonstrate how combinatorial tools were used to accelerate the effort to commercialize this catalyst, PI-242^TM (UOP LLC). This presentation will demonstrate how combinatorial tools can be used to greatly accelerate the discovery and subsequent commercialization
of heterogeneous catalyst products.

3:30 Refreshment Break, Poster/Exhibit Viewing

3:50 Optimal Materials Library Design
David B. Nicolaides, PhD, Product Manager, Materials Business Unit, Accelrys, Ltd., United Kingdom
The pharmaceuticals discovery community has realized that they must step back from HT for HT's sake, and include into their process the chemical knowledge (e.g. "drug-likeness"), which was the focus of their activities before HTS. This impacts the rational design of libraries in the materials domain. We discuss the common methods used in designing pharma and materials libraries, and put these examples in context by discussing how best to manage library data throughout the discovery process.

4:25 VirtualLab - Integrated Design, Execution, & Analysis Tools for Today's Researcher
Donald W. McDowell, Chief Operating Officer, Avantium Technologies, Inc.
VirtualLab is an integrated software suite that provides chemists the ability to generate workflows for designing, executing, and analyzing experiments using both automated, high throughput equipment technology and traditional bench top chemistry in a secure, compliant environment. Avantium's Data Analysis Pipeline (DAP) Tool is desktop software that provides the scientist with a simple 'drag & drop' graphical manner of creating data analysis workflows.

5:00 Gradient Library Calibration - Practices for Gradient Combi Techniques
Michael J. Fasolka, PhD, Materials Research Engineer, Polymers Division, NIST Combinatorial Methods Center, National Institute of Standards and Technology*
As opposed to discrete specimen arrays, gradient combinatorial libraries gradually and continuously vary in their properties. In addition, this variation can be non-linear in one or more spatial coordinates. Accordingly, gradient libraries require calibration (i.e. characterization of the gradient scope and shape) for accurate property measurement, property correlation and effective automation/workflow. In this talk, we describe gradient calibration practices developed at NIST and the opportunities proper calibration present.
*In collaboration with: A.Karim, E.J.Amis, NIST

5:20 Panel Discussion

Combi - Information to Knowledge

Eric J. Amis, NIST

W. Nicholas Delgass, Purdue University
Jochen Lauterbach, University of Delaware
Tudor I. Oprea, University of New Mexico
Krishna Rajan, Rensselaer Polytechnic Institute
Brian K. Southern, Accelics, Inc.
Ichiro Takeuchi, University of Maryland

8:00 Registration, Poster/Exhibit Set-Up, Coffee and Pastries

8:45 Chairperson's Opening Remarks
Brian K. Southern, PhD, President, Accelics, Inc.

9:00 KEY NOTE - High Throughput Catalytic Science
Jochen Lauterbach, PhD, Professor, Dept Chemical Engineering, University of Delaware
The ability to study catalysts under non-steady-state conditions is vital to the understanding and development of catalysts. We have developed an experimental methodology that combines the ability to study multiple catalyst samples in
real time at a precision that allows for detailed kinetic modeling. This allows us to rise above simple high-throughput screening to the level of fundamental understanding of reaction mechanisms and marks the dawn of a new field of
scientific endeavor: high throughput catalytic science

9:45 KEY NOTE - Challenges and Frontiers in Combinatorial Materials Science
Ichiro Takeuchi, PhD, Assistant Professor, Dept Materials and Nuclear Engineering and Center for Superconductivity Research, University of Maryland
We will discuss technical as well as non-technical issues we encounter in implementing the combinatorial methodology to different aspects of materials science and to topics of immediate technological interests. The emphasis will be on inorganic thin film materials. We will try to answer the question: how can we bring the combinatorial approach to the forefront of mainstream experimental techniques?

10:30 Refreshment Break, Poster/Exhibit Viewing

11:00 Combinatorial Tools Applicable to Inorganic Materials Research
Debra L. Kaiser, PhD, Group Leader, Ceramics Division, National Institute of Standards and Technology
Over the past several years, the NIST Ceramics and Metallurgy Divisions have been developing high throughput tools for fabricating and characterizing inorganic materials. Tools include pulsed laser deposition and e-beam evaporation for fabricating film libraries, Near-Edge X-ray Absorption Fine Structure, transmission electron microscopy, and electron energy loss spectroscopy for characterizing nanoscale structure and chemical nature, spectroscopic reflectometry for measuring film thickness and refractive index, and magneto-optical imaging for determining magnetic properties. Applications of these techniques to electronic, optoelectronic, magnetic and catalytic materials will be presented.

11:30 Examples of Inorganic Materials Discovery and Optimization Using the Combinatorial Approach
Martin Devenney, PhD, Director, Electronic and Related Materials, Symyx Technologies, Inc.
Examples will be shown of how the combinatorial approach has been successfully implemented and used in inorganic materials discovery programs at Symyx Technologies. High throughput syntheses and screening techniques and materials discoveries from combinatorial programs directed towards X-ray storage phosphors, phosphors for lighting applications and materials for microelectronics applications will be presented to demonstrate the utility of the approach.

12:00 Combinatorial Coatings Development
James N. Cawse, PhD, Senior Staff Scientist, GE Global Research, General Electric Company, and
Jay Akhave, Avery Research Center
GE Global Research and Avery Research Center have recently completed a three-year NIST ATP program for development of combinatorial methods applied to coatings research. We will review some of the important advances that have been
made in high throughput methods for forming, curing and evaluating coatings. Advances include techniques of producing uniform small coatings samples and small-scale measurements of adhesion, abrasion, barrier, and weathering properties.
This has been applied to such applications as barrier coatings and automotive hardcoats.

12:30 Luncheon Sponsored by The Knowledge Foundation, Inc.

1:55 Chairperson's Remarks
Radislav A. Potyrailo, PhD, Analytical Chemist, Combinatorial Chemistry Laboratory, Corporate Research and Development, General Electric Company

2:00 Creating Commercial Value by Using Combi
Jennifer S. Holmgren, PhD, Director, Exploratory and Fundamental Research, UOP LLC*
Recently, UOP commercialized a new catalyst, which was discovered using our integrated combinatorial chemistry system. In this case, combi was not only used to enable the catalyst discovery but also to develop an understanding of the chemistry and accelerate the scale-up and commercialization. This is the first example of a commercial combi innovation in the heterogeneous catalyst area. The talk will focus on this and other examples where we have demonstrated the use of combi to accelerate the entire commercialization life cycle.
*In collaboration with: R.Gillespie, M.Bricker, R.Rosin, A.Sachtler, Y.Le, H.Vega, R.Willisa, UOP LLC; D.Akporiaye, A.Karlsson, M.Plassen, R.Wendelbo, SINTEF, Norway; and D.S.Bem, Torial Technologies

2:30 Accelerated Product and Process Development
Gert-Jan M. Gruter, PhD, Professor, Vice President, Technology, Chemicals, Avantium Technologies BV, The Netherlands
Avantium's high throughput experimentation tools are designed not only to enable fast lead generation, but also assist in optimization and scale-up of a material, formulation, catalyst or process lead. In addition, Avantium is applying realistic testing conditions on a small scale. The latest achievement in this area is the worlds first 32 barrel fixed bed trickle flow screening unit. By generating kinetic models Avantium has the possibility to assist the scale-up process even further by using reactor & process simulation.

3:00 Materials Studies on MEMS Microhotplate Arrays
Steve Semancik, PhD, Physicist / Project Leader, Chemical Microsensor Program at NIST, Chemical Science and Technology Laboratory, National Institute of Standards and Technology*
Temperature is often a key parameter in the fabrication and performance of materials. This presentation describes the use of micromachined "microhotplate" arrays to study, in parallel,temperature-dependent processing/property/performance relationships for thin films. The ~100 µm x 100 µm microhotplate elements have individually addressable heaters (rapid control from 20°C to 750°C) and surface electrodes (for electrically characterizing deposited films). Various methods, including thermally-activated CVD and addressable electrochemistry, have been employed to locally deposit oxide, metal and polymeric microsamples. Case studies on solid state gas sensing materials will be discussed to illustrate experimental methods which can be generalized to a variety of technological areas.
*In collaboration with: C.Taylor, and R.Cavicchi, NIST

3:30 Refreshment Break, Poster/Exhibit Viewing

4:00 Exploration of New Thermoelectric Oxides Using a Combinatorial Technique
Ryoji Funahashi, PhD, Special Division of Green Life Technology, National Institute of Advanced Industrial Science and Technology, Japan*
New n-type thermoelectric oxides are being explored using a combinatorial technique, in which 1000 specimens can be prepared and estimated their thermoelectric properties a day. The water solutions of metal nitric acid are used as starting materials. One library with 100 specimens on a 100 x 100 mm alumina plate can be prepared for an hour. Thermoelectric power is measured using a two terminal method by 250 specimens/h. In the ternary system, La-Ni-O is found out to show n-type thermoelectric properties.
*In collaboration with: S.Urata, AIST, and M.Kitawaki, Osaka Electro-Communication University, Japan

4:30 Optimizing Nanostructure Growth for Sensor Applications Using High Throughput Methodology
Alan M. Cassell, PhD, Senior Research Scientist, Center for Nanotechnology, NASA Ames Research Center
As we strive to harness the advantages of nanomaterials for applications in nanoelectronics, optoelectronics and sensing applications, controlling the patterning, placement, selectivity and function of heterogeneous catalysts becomes a prime consideration. There are a number of high throughput strategies that can be implemented to rapidly optimize the specific structures and properties that are desired. A brief description of our discovery methodology with attention towards rapid sensor applications development will be discussed.

5:00 Combinatorial Approach for Nano-Scale Fabrication and Understanding of Surface and Interface
Yuji Matsumoto, PhD, Research Associate, Tokyo Institute of Technology, Japan
There has been a growing interest in nano-science and/or -technology that has much to do with atomically controlled epitaxy and nano-fabrication of materials. In this paper, we will demonstrate that combinatorial approach is also effective for nano-scale fabrication and for understanding of the surface and the interface in a thin film growth and catalysis, showing some recent development of high-throughput surface characterization as well as film masking technology.

Friday, February 21, 2003

8:15 Poster/Exhibit Viewing, Coffee and Pastries

8:55 Chairperson's Remarks
Ichiro Takeuchi, PhD, Assistant Professor, Dept Materials and Nuclear Engineering and Center for Superconductivity Research, University of Maryland

9:00 KEY NOTE - Combinatorial Materials Science: Exploring the Wonder World of Complex Materials
Xiao-Dong Xiang, PhD, Chief Technology Officer, Intematix Corporation
Looking back to the last 10 years achievement of combinatorial materials science, from the early work on high-T_c superconductors as a proof of principle, to the discovery of novel giant magneotoresistive, luminescent and dielectric materials, from the synthesis of polycrystalline discrete materials libraries to the epitaxial growth of continuous materials phase diagrams, from the invention of evanescent microwave probe for electric impedance mapping to the recent invention of spin resonant probe for intrinsic magnetic properties, whence considered unrealistic fantasies are now realities. I will discuss some recent breakthroughs and foresee future directions in this field.

9:45 KEY NOTE - A Combinatorial Approach to Polymeric Biomaterials: Library Preparation, Screening and Analysis
Eric J. Amis, PhD, Chief, Polymers Division, National Institute of Standards and Technology
Efforts in combinatorial biomaterials science at NIST have evolved into three interwoven tool sets for exploring cellular response to materials: material library preparation, high-throughput screening, and statistical treatment of population distributions. High-throughput techniques are being used to screen (initially polymeric) material libraries and an informatics approach is being developed to compare the results between experiments and response functions that link materials, culture conditions, and cellular response. This includes the characteristics of crystallinity, modulus, hydrophobicity, charge, and blend morphology. Another class of materials will be based on organizing physicochemical as well as biochemical components using patterning, phase separation, and self-assembly processes in a manner that presents cells with a similar, highly structured environment as they experience in vivo.

10:30 Refreshment Break, Poster/Exhibit Viewing

11:00 Dynamic Combinatorial Libraries for Materials Science: Accelerating Discovery for Industry
Krishna Rajan, PhD, Professor, Dept Materials Science & Engineering and Faculty of Information Technology, Rensselaer Polytechnic Institute
The present mode of synthesizing solid state materials using combinatorial methods focus primarily on techniques which rely on creating some form of diffusion couple and complex geometries that permit contact between the reacting components. In the thin film form, diffusion can occur within a reasonable period of time with annealing treatments. In bulk form, much longer times are needed. In this presentation, we discuss a totally different approach, where the initial solid state reaction to form a compound in itself leads to a self propagating reaction, leading to the formation of new compounds and chemistries at a very high rate, in the order of seconds in some cases. This dynamic library offers the potential of very high throughput materials synthesis by overcoming the kinetic barrier in solid state libraries. With this new approach, combinatorial materials science may in fact start approaching the organic chemistry and drug discovery fields in rate of materials production. The potential impact on industrial needs in materials science is also discussed.

11:30 Combinatorial Libraries for Functional Materials:
From Thin Films to Bulk Ceramics
Wolfgang Rossner, PhD, Project Manager, Corporate Technology, Siemens AG, Germany*
Combinatorial methods offer the advantage to greatly accelerate materials discovery. However, it is advantageous to establish a broad spectrum of synthesis techniques in order to provide a sample consistency, which guarantees a reliable screening of properties. In cases where the materials microstructure is affecting the properties like in polycrystalline ceramics it is required to obtain bulk libraries. The progression from thin film libraries by sol-gel methods to bulk ceramic sample arrays is discussed.
*In collaboration with: B.Wessler

12:00 Sensor Arrays for High-Throughput Design, Performance Testing, and Characterization of Complex Materials
Radislav A. Potyrailo, PhD, Analytical Chemist, Combinatorial Chemistry Laboratory, Corporate Research and Development, General Electric Company*
We developed a general scheme for materials screening that incorporates combinatorial fabrication, high-throughput performance testing (HTPT), and characterization steps. Our testing process imitates the end-use application and alters materials properties that are impossible to quantitatively predict using existing knowledge. This strategy is applicable for combinatorial development of materials for engineering, aesthetic, and other applications, when screening for intrinsic materials properties does not provide information about their long-term performance. We demonstrated our strategy for HTPT of polymeric materials for sensor and other applications using acoustic-wave sensor arrays.
*In collaboration with: W.G.Morris and R.J.Wroczynski, GE

12:30 Lunch on Your Own

1:55 Chairperson's Remarks
Alamgir Karim, PhD, Group Leader, Multivariant Measurement Methods Group, Polymers Division, National Institute of Standards and Technology

2:00 The Application of the Compositional-Spread Approach to the Discovery of Materials for MEMS
Ainissa G. Ramirez, PhD, Assistant Professor, Dept of Mechanical Engineering, Yale University
The rapid growth of MEMS incites the need for the creation of new thin-film materials for these devices. One means of enabling this accelerated pace is through a high-throughput discovery tool called the compositional-spread technique.
Using this technique, gold-cobalt thin-film alloys for contact materials of MEMS microrelays were deposited and subjected to heat treatments for hardening by precipitates. Accordingly, a breadth of precipitation structures are formed in gold using varying cobalt amounts that can be imultaneously synthesized, heat-treated, and characterized. These materials are then evaluated for mechanical hardness, conductivity, and composition using four-point probe, nanoindentation, and XPS. The compositional-spread approach was also applied to the development of robust TiNi shape-memory alloys for MEMS. Using MEMS test structures of various compositions; actuation properties can be rapidly mapped. From this method one can trend the material's structure-property relationship and can generate films that best suit applications. This talk presents the experiments and technique for selecting favorable alloys.

2:30 Combinatorial Ternary Phase Diagramming for Discovery of New Materials in the Future ULSI
Toyohiro Chikyow, PhD, Senior Researcher, Nano Material Research Laboratories, National Institute for Material Science (COMET-NIMS), Japan
For the increasing number of transistors on Large Scale Integrated Circuit (LSI), finding a new gate insulator becomes a top priority issue in ULSI industry. The new material is amorphous as well as higher dielectric material. For discovering a new gate insulator, newly designed combinatorial growth system is developed. In this system, a ternary phase diagramming and binary phase diagramming are demonstrated simultaneously on a substrate. Throughout the experiments, a candidate of the new gate insulator will be presented on the day.

3:00 High-Throughput-Technologies in the Development of Chemical Gas Sensor Materials
Thomas Brinz, PhD, Corporate Research and Development, Applied Chemistry, Robert Bosch GmbH, Germany
Gas sensor technology is one of the most important mass-markets of the future with a constantly increasing number and variety of applications in both the industrial and the private sector. The actual requirement for intelligent new materials for chemical gas sensor technology could never be covered satisfactorily using conventional methods. The amount of variable parameters makes the search for sensors with optimal characteristics very time consuming or even impossible. Here combinatorial chemistry offers an alternative perspective, with which high sample throughput is attainable through parallelism and miniaturization. This new opening is the subject of the BMBF network project "KOMBISENS", which is promoted under the category of "chemical technologies". Novel combinatorial techniques and procedures for the discovery of new organic and inorganic sensor materials are introduced. Apart from the chemical development of new materials and appropriate synthesis strategies, initially the development of apparatus and instrumentation was the main focus of the project.

3:30 Refreshment Break, Poster/Exhibit Viewing

4:00 Ink-Jet Methods in Combinatorial Materials Discovery
Donald J. Hayes, PhD, President, MicroFab Technologies, Inc.
The application of demand mode ink-jet printing technology to high throughput combinatorial synthesis of materials is discussed. This technology can reproducibly create and direct spheres of fluid with diameters of 15 - 100 Fm (2 - 500
pl) at rates of 0 - 25,000 per second. Piezoelectric demand mode technology is able to dispense a wide range of materials, including organic solvents, polymers, bioactive molecules, and particle dispersions, at spatial resolutions that allow greater than 2,000 synthesis sties per square centimeter to be created. Ink-jet technology is also inherently digital controlled and a non-contact.

4:30 Development of Molecularly Imprinted Polymers via Parallel Synthesis and Testing in a 96-Well Plate Format
Börje Sellergren, PhD, Institut für Umweltsforschung, Universität Dortmund, Germany
Molecularly imprinted polymers (MIPs) are presently made and used in many laboratories to achieve highly selective separations of a large variety of target molecules. In order to facilitate the search for optimum synthesis protocols, a technique allowing high throughput synthesis and evaluation of molecularly imprinted polymer sorbents at a reduced scale (mini-MIPs) was developed. Examples of how the latest version of the technique has been applied to either improve existing MIPs or to search for entirely new materials compositions
will be given.

5:00 Open Discussion and Concluding Remarks

5:15 End of Conference

Call for Posters

Industry and academic scientists are encouraged to submit poster presentations for this event. One-page abstracts along with the title of presentation (8 1/2” x 11” with 1-inch margins) must be submitted no later than January 15, 2003 for inclusion in conference documentation. Additional poster submissions will be accepted until February 1, 2003 but may not be included in conference documentation.

Note: If you're submitting a poster, you MUST be registered and paid registration fee plus posterboard reservation fee in advance to ensure that a posterboard is reserved for you.

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