Conveniently Timed and Co-Located With     
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  Biodetection Agenda   
  Biosurveillance Agenda   
  Sponsoring Opportunities   
  Food Safety Agenda   

The National Strategy for Biosurveillance (Strategy) calls for “a coordinated approach that brings together Federal, state, local, and tribal governments; the private sector; nongovernmental organizations; and international partners” to enhance existing biosurveillance capabilities and, where necessary, develop new ones that provide decision makers and responders with the essential information they need to mitigate impacts of threats to health and associated economic, societal, and political consequences. The Strategy recognizes that a well-integrated national biosurveillance enterprise can saves lives by providing essential information for better decision making at all levels.

The National Biosurveillance (BSV) Science and Technology (S&T) Roadmap, published in June 2013, identifies and prioritizes the R&D efforts needed to provide decision makers at all levels with the accurate and timely information needed to develop effective responses to incidents that threaten health. The R&D objectives in this Roadmap are designed to facilitate the accomplishment of the core functions and actions identified in the Strategy and Implementation Plan, respectively. Consistent with the Strategy and Homeland Security Presidential Directive (HSPD)-21 entitled Public Health and Medical Preparedness, this Roadmap focuses on S&T for anticipating significant health incidents involving naturally occurring, accidental, or manmade threats; rapidly and accurately identifying and characterizing incidents that occur; and effectively integrating, sharing, and analyzing the information available at each stage. Achieving the S&T objectives in this Roadmap will permit better decision making during an incident, resulting in improved mitigation, response, and recovery2 that may ultimately save lives and improve health.
This symposium will address The National Strategy for Biosurveillance identified core functions which include:
Aberration detection – Define and prioritize R&D needed to establish the baseline condition of the environment and/or human (including vulnerable subpopulations), animal, or plant populations that is sufficiently robust to permit rapid identification of aberrant incidents to drive preparedness and timely, focused investigation.

Risk anticipation – Define and prioritize R&D needed to identify antecedent conditions and characterize complex interactions that permit prediction of an impending natural or intentional incident and to forecast impacts from such incidents.

Threat identification and characterization – Define and prioritize R&D needed to ensure exposures and health threats are identified rapidly and accurately and can be sufficiently characterized to provide needed information to decision makers, including responders and healthcare providers.

Information integration, analysis, and sharing – Define and prioritize R&D needed to enable improved integration, sharing, and analysis of BSV data in near real-time and in a format that provides essential information to decision makers, including responders and healthcare providers.

Thursday, June 12, 2014 

8:00  Registration with Morning Coffee 
8:45 Chairperson’s Welcome and Opening Remarks
John Doesburg, International Security & Analysis Programs, Oak Ridge National Laboratory (ORNL) 
9:00  Biosurveillance Portal: Situational Awareness for the Department of Defense
C. Nicole Rosenzweig, PhD, Research Biologist, Edgewood Chemical Biological Center, U.S. Army RDECOM Laboratory
The Joint Program Executive Office (JPEO) is the Joint Services manager for acquisition and fielding information management systems for the Warfighter.  Currently, JPEO is executing an Advanced Technology Demonstration (ATD) which includes an informatics effort: the Biosurveillance Portal.  To support the situational awareness needs of the Warfighter, development of a common informatics architecture is the first order of business.  To this end, the Operational Release of the Biosurveillance Portal is October, 2014.  With this defined software stack, the portal will support seamless communication and data sharing in the US Pacific Command.  The user base will be expanded to other US Commands in FY15, with functionality expansion planned for each release.
9:30  National Biosurveillance Integration Center Enabling Shared Situational Awareness of Acute Biological Events Through Rapid Identification, Characterization, Localization and Tracking
Steve Bennett, Ph.D. Director, National Biosurveillance Integration Center, Office of Health of Affairs, U.S. Department of Homeland Security 

10:00  Scalable “Big Data” Machine Learning for Bio-surveillance
Arvind Ramanathan, Ph.D., Computational Biologist, Oak Ridge National Laboratory and Laura Pullum, Ph.D., Research Scientist, Oak Ridge National Laboratory

As the number of data sources for public health surveillance continues to grow both in volume and variety, there is a need to develop data-driven machine learning tools that can automate discovery and aid decision makers in obtaining quantifiable insights on emerging disease spread phenomena. In this talk, we present an overview of scalable machine learning tools that we have been developing as part of advancing this mission. In particular, our machine learning tools can automatically (1) detect multi-scale spatial and temporal break-out patterns of disease occurrence, (2) quantify multi-modal co-occurrence disease patterns to identify local- and national-level “hotspots” and (3) predict how patterns of co-occurrence correspond to ‘intervention’ strategies. We will present vignettes of our toolset in the context of analyzing both social media and electronic health transactional data and demonstrate its applicability in a retrospective analysis of the 2009-2010 H1N1 flu season.  

10:30  Coffee with Exhibit & Poster Viewing 
11:00  U.S. Government Perspective on Medical Preparedness for the National Strategy for Biosurveillance
Susan Coller Monarez, Ph.D., Director for Medical Preparedness Policy, National Security Council Staff, Executive Office of the President of the United States 
11:30  Common Platforms for Diagnostic and Environmental Assays Provide Comprehensive Situational Awareness for Diverse Missions
Amy L. Altman, Ph.D., Vice President, Biodefense, Luminex Corporation
Ensuring the safety of our food supply is critical as unsafe food accounts for millions of deaths and cases of disease annually. Our ability to quickly detect and characterize an outbreak of a food-borne illness, whether due to a bioterrorist event or inadvertent food contamination, is critical for saving lives and minimizing the economic impact of such an incident. Foodborne illness is a growing public health problem and sensitive and accurate detection of the causative agent presents unique instrumentation and assay challenges. Determining the source of the outbreak also presents challenges as the first sign of a potential food borne outbreak is typically a surge of patients seeking medical care for gastrointestinal symptoms. To provide more comprehensive situational awareness, efforts at Luminex include developing both a more comprehensive assay menu and a suite of instruments to address varying mission needs from high throughput laboratories to field assessment. Open-architecture xMAP® technology allows simultaneous detection of bacterial, viral and toxin agents, in a highly flexible, multiplexed architecture capable of protein and nucleic acid assay formats. We will discuss how diagnostics and environmental detection assays can work synergistically to provide timely and accurate answers.
12:00  Lunch on Your Own 
1:30  DTRA’s  Biosurveillance Ecosystem
Ronald K. Hann Jr., Ph.D, Director CB Technologies, Defense Threat Reduction Agency/Joint Science and Technology Office (DTRA/JSTO) 
2:00  Integrative Biosurveillance
Harshini Mukundan, PhD, Principal Investigator, Chemistry Division, Los Alamos National Laboratory
Biosurveillance requires the integration of complex data from variant sources. Herein we present some of the critical technological tools that can advance that ultimate mission: from advanced diagnostics for pathogen characterization to modeling algorithms. Specifically, we will outline the advancements made and lessons learned in applying these tools to a real world population in rural Kenya. This work is a collaboration between the Los Alamos National Laboratory and the University of New Mexico (center for global health).    

2:30  Development of a JUPITR/GBTI Exemplar Training Laboratory for Evaluation and Optimization of Capability: A new approach.
David L Hirschberg, Assistant Professor of Clinical Pathology & Chief Technology Officer, Columbia University
A Joint USFK Portal and Integrated Threat Reduction (JUPITR) Advanced TEchnology Demonstration (ATD) and Global Biosurveillance Technology Initiative (GBTI) Exemplar laboratory located at Edgewood Chemical Biological Center (ECBC) will serve as a resource for many stakeholders and fulfill several programmatic roles. A testbed for component, reagent, and bioinformatics upgrades, the lab will optimize capabilities in biosurveillance technologies and function as a operation training laboratory for the US Army Public Health Command. The laboratory will also serve as a technology demonstration site for US Army Test and Evaluation Command assessment of JUPITR ATD capabilities ahead of operational demonstration by US Forces Korea (USFK) in 2015.
3:00  PANEL DISCUSSION: R&D Objectives of The National Strategy for Biosurveillance
John Doesburg, International Security & Analysis Programs, Oak Ridge National Laboratory (ORNL)
C. Nicole Rosenzweig, PhD, Research Biologist, Edgewood Chemical Biological Center, U.S. Army RDECOM Laboratory
Harshini Mukundan, PhD, Principal Investigator, Chemistry Division, Los Alamos National Laboratory
Matthew Lesho, PhD, Director, Government Business Development, Luminex Corporation
David L Hirschberg, Assistant Professor of Clinical Pathology & Chief Technology Officer, Columbia University
3:30  End of Symposium  
Industry, government and academic scientists are encouraged to submit poster titles for this event. One-page abstracts (8 1/2" x 11" with 1-inch margins) must be submitted via e-mail: SUBMIT@knowledgefoundation.com no later than May 10, 2014 for inclusion in conference documentation. Additional poster submissions will be accepted until May 25, 2014 but may not be included in conference documentation.

DIMENSIONS of the poster boards are: 
4 feet wide by 3 feet high 
(although posterboards could be placed vertically as well and then the dimentsions obviously would be 3' w x 4' h, or 90 x 120cm accordingly). 

Note: If you're submitting a poster, you MUST be registered and paid registration fee plus posterboard reservation fee in advance to ensure that a posterboard is reserved for you. 
Registration fee includes access to the Conference, refreshments, access to posters and exhibit, and all documentation made available to us by speakers. 

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* On-site registration - add US $100 to below amounts 

Commercial Registration: 
Biosurveillance Symposium Only (June 12, 2014): 
Non-member: US $449 
Member: US $381 
3 DAY - Biodetection, Biosurveillance & Food Safety (June 10-12, 2014): 
Non-member: US $1399.00 
Member: US $1189.15

Academic/Government Registration*:  

Biosurveillance Symposium Only (June 12, 2014): 
Non-member: US $349 
Member: US $296  
3 DAY - Biodetection, Biosurveillance & Food Safety (June 10-12, 2014): 
Non-member: US $999.00 
Member: US $849.15
Poster Space Reservation fee: 
US $79 (you must be registered for the Conference) 
*The academic/government rate is extended to all participants registering as full time employees of government and universities. To receive the academic/government rate you must not be affiliated with any private organizations either as consultants or owners or part owners of businesses. 

Payment: All payments must be made in U.S. funds drawn on a U.S. bank. Please make check(s) payable to The Knowledge Foundation and attach to the registration form even if you have registered by phone, fax or e-mail. To guarantee your registration, payment must be received prior to the conference. Confirmation of your booking will follow. 

Discount Accommodations and Travel: 
A block of rooms has been allocated at a special reduced rate. Please make your reservations by October 21, 2013 to obtain this rate. When making reservations, please refer to The Knowledge Foundation. Contact The Knowledge Foundation if you require assistance. 

Conference Venue:
Baltimore Harbor Hotel 
(formerly Sheraton Baltimore City Center Hotel) 
101 West Fayette Street
Baltimore, MD  21202
A substitute member of your company may replace your attendance at any time at no charge if you find your schedule prevents you from attending. Please notify us immediately so that materials can be prepared. If you do not wish to substitute your registration, we regret that your cancellation will be subject to a $100 processing fee. To receive a prompt refund, we must receive your cancellation in writing 30 days prior to the conference. Unfortunately cancellations cannot be accepted after that date. In the event that The Knowledge Foundation cancels an event, The Knowledge Foundation cannot resume responsibility for any travel-related costs.