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Los Alamos National Laboratory's Harshini Mukundan to Present 'Addressing Complex Clinical Problems with Novel Diagnostic Strategies'

Los Alamos National Laboratory's Harshini Mukundan to Present "Addressing Complex Clinical Problems with Novel Diagnostic Strategies" at Biodetection Technologies Conference in Baltimore 


22nd International Conference
Biodetection Technologies
Technological Advances in Detection & Identification of Biological Threats
June 10-11, 2014 | Baltimore, MD


BIODETECTION TECHNOLOGIES 2014 - the 22nd conference in our Detection Technologies conference series - is an internationally recognized meeting for experts in detection & identification of biological threats and point-of-care analytical methods. This conference will review feedback from the end-users on biodefense and biomedical technologies and explore the cutting-edge in R&D and commercialization efforts in the field, including:


  • Rapid biosensing, biodetection and analysis
     
  • Simultaneous detection of multiple threats and pathogens
     
  • Discovery and analysis of biosignatures for the detection of host response
     
  • Point-of-care/clinical applications for pathogen/virus/threat detection and identification
     
  • Point-of-care assays for resource limited, lab and clinical settings; mobile labs
     
  • Advances in microarray and sequencing technologies
     
  • Field-deployable devices: portability/compatibility/reliability/scalability
     
  • Non-PCR vs. PCR based detection techniques
     
  • Issues of sensitivity/testing/evaluation/validation
     
  • Animal and plant pathogens
     
  • Bioelectronics
     
  • DNA chips, nucleic acid sensors and aptasensors
     
  • Enzyme-based biosensors
     
  • Immunosensors
     
  • Lab-on-a-chip
     
  • Microfluidics and immobilisation technology
     
  • Natural & synthetic receptors (including MIPs)
     
  • Organism- and whole cell-based biosensors
     
  • Proteomics, single-cell analysis and cancer-cell detection
     
  • Signal transduction technology (including magneto, piezo, optical and direct electrochemical techniques)

Featured Presentation: 

Addressing Complex Clinical Problems with Novel Diagnostic Strategies 

Harshini Mukundan, PhD, Research Scientist, Los Alamos National Laboratory 

Dr. Mukundan will discuss advanced and integrated biodiagnostic strategies at LANL, spanning from rapid biomarker detection to advanced sequencing based analysis, to understand the circulation, emergence and occurrence of drug resistance in a pediatric population in rural Kenya. In addition, she will also talk about novel detection strategies used for the detection of bacterimia, including active tuberculosis, for the first time in this population.


Dr. Mukundan is a scientist and principal investigator at the Los Alamos National Laboratory. Following a PhD in biomedical sciences and three year industry experience developing hand held robust sensors for pathogens, Harshini joined Los Alamos with a prestigious NIH post-doctoral fellowship. Her team is focused on the development of ultra-sensitive and specific detection assays for pathogens of interest to global health and national security. The research effort of the multi-disciplinary biosensor team focuses on engineering new sensor systems (waveguide-based optical biosensor platforms), transduction schemes (membrane insertion technology), functional surfaces (silane based self assembled monolayer chemistry), recognition ligands (recombinant antibodies, carbohydrates and aptamers) and fluorescence reporters (quantum dot conjugated recognition ligands). This integrated approach has been used to develop diagnostic assays for agents such as mycobacterium tuberculosis, bacillus anthracis, serotype specific detection of influenza viruses, and others. More recently, the team has been working to develop rapid diagnostics for Shiga-toxin carrying E. coli, a concern to the beef industry, and extending the technology for M. tuberculosis detection to full-scale clinical studies, among others. The team is also interested in using the strategies developed to understand host-pathogen biology, especially in the context of innate immune recognition of pathogen associated molecular patterns during infection, processes that have significant impact on the design of both vaccines and countermeasures.

CONFERENCE-AT-A-GLANCE 


GENE AMPLIFICATION FOR BIOLOGICAL TARGET IDENTIFICATION 

Increased Discrimination of Pathogens and Blood Donor Sample Multiplex Testing with an OpenArray Platform 

Robert Duncan, PhD, Staff Scientist, FDA Center for Biologics Evaluation and Research, U.S. Food and Drug Administration 

Treatment Guiding Detection of Burkholderia 

R. Paul Schaudies, PhD, CEO, GenArraytion, Inc. 

Conductive DNA Real-Time Simultaneous Detection of Multiple Targets 

Fred Albert, PhD, President, Bridger Technologies, Inc. 

A Fully Autonomous Biodetection System for Environmental Surveillance 

Mark Burton, Northrop Grumman Corporation 

Addressing Complex Clinical Problems with Novel Diagnostic Strategies 

Harshini Mukundan, PhD, Research Scientist, Los Alamos National Laboratory 

Enabling Point of Care Test Development for the STD Market 

Joany Jackman, PhD, Investigator, Center for Point of Care Tests for STD, Johns Hopkins University School of Medicine 


NOVEL DETECTION STRATEGIES FOR BIOLOGICAL TARGETS 

Direct Multiplexed Virus Detection 

John H. Connor, PhD, Professor, Dept of Microbiology, Boston University School of Medicine 

Optimization of a Lateral Flow Immunoassay (LFI) for the Rapid Diagnosis of Melioidosis 

David AuCoin, PhD, Research Assistant Professor, Dept Microbiology and Immunology, University of Nevada School of Medicine 

Towards PCR-Free, Visual DNA Detection 

Mahesh Uttamchandani, PhD, Assistant Professor, DSO National Laboratories, National University of Singapore, Singapore 

Magneto-Hydrodynamic Focusing for Point of Care Applications 

Christian Reis, Group Lead - Biotechnology Processes, Fraunhofer IPA, Germany 

Bioaerosol Standoff Detection Using Lidar Technology Allowing Cloud Mapping and Spectrometric LIF Classification 

Sylvie Buteau, PhD, Scientist, Defence Research and Development Canada, Canada 

iTIRF - Cell Phone Based Biosensor for Molecular Diagnostics 

Alexander N. Asanov, PhD, President and CSO, TIRF Labs, Inc. 

Genomic-Based Approach for Tracking and Discriminating Pathogens 

Willy Valdivia-Granda, PhD, CEO, Orion Integrated Biosciences Inc. 


CHEMICAL AND TOXIN DETECTION 

Novel Cell-Based Assay for Testing Active Ricin in Environmental Samples 

Baolin Zhang, PhD, Senior Investigator, Division of Therapeutic Proteins, Office of Biotechnology Products, Food and Drug Administration 

Automatic Online Real-Time Detection of Microcystin-LR Based on Optical Biosensing System 

Han-Chang Shi, PhD, Professor, School of Environment, Tsinghua University, PR China 

Microcantilever Enabled Biodetection 

Rick Venedam, PhD, Senior Scientist, National Security Technologies, LLC 

The Photonic Nose: A Versatile and Simple Sensing Tool 

Leonardo Bonifacio, PhD, Research Scientist, Opalux Inc., Canada 

New MEMS-based Micro-Coriolis Density Measurement Technology 

Mike Touzin, Endress+Hauser Flowtec, Switzerland 

Mid-Infrared QC Lasers for Molecular Recognition 

Mariano Troccoli, PhD, Director of Product Development, AdTech Optics, Inc. 

Host-Response Based Biodetection by Immunosignatures 

Stephen Albert Johnston, PhD, Co-Director, Center for Innovations in Medicine, Professor, School of Life Sciences, Biodesign Institute, Arizona State University 


TOOLS FOR DETECTION - MICROFLUIDICS AND ENZYMES 

Tool Box of Engineered Microfluidic Components Shortens Development Time and Reduce Risk 

Leanna Levine, PhD, CEO, Aline, Inc. 

SoundStream - A Microfluidic-Based Assay Platform for Rapid Portable Diagnostics 

Arlene Doria, PhD, CEO, DEFINEQA Inc. 

Application of a Recombinant Topoisomerase for the Specific Enrichment of Prokaryotic DNA 

Natalia Sandetskaya, PhD, Fraunhofer Institute for Cell Therapy and Immunology IZI, Germany 

A Novel Thermostable Viral DNA Polymerase Facilitates Point of Care Molecular Detection of DNA and RNA Targets 

Hemanth Shenoi, PhD, Lucigen Corp. 


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